5-MeO-DMT has been used as an entheogen by South American shamans for thousands of years and induces mystical experiences
It increases the intensity of physical and tactile sensations to such an overwhelming extent that it can induce a sensation of sustained and repeatable full body orgasm within every nerve ending across the entire body
Like DMT, this drug is evidently not active orally. Smoked it is about four times the potency of DMT. Shulgin conducted experiments with nine subjects, finding that smoking 6-10 mg of the free base of 5-MeO-DMT produced an entheogenic effect starting in less than 60 seconds, reaching a peak in two to three minutes and lasting about twenty minutes.
5-MeO-DMT is not one of the SAMHSA-5, the five drugs tested for in U.S. government-approved basic drug tests. 5-MeO-DMT is also not tested for in typical extended drug tests. It is not chemically similar to any of the drugs tested for, so should not trigger the tests as another substance.